This monograph provides the baseline data and treatment outcome to students, researchers and clinicians about Human Papillomavirus (HPV) related oral squamous cell carcinoma. The objective of this monograph is to shed the light on the vast increment of oral cancer in Malaysian population and HPV has been proven to be the caused for such increased in oral cancer. This monograph is well structured so everybody can understand easily. This monograph can be used as guideline information on the treatment outcomes for patients treated in Malaysia mainly to reflect on the current state of patient management and treatment outcomes. This is important as it may act as a baseline information to focus on the future establishment of more effective management strategies, mainly targeting on the treatment protocols and patient education in local government hospitals. Hopefully this monograph will provide valuable findings and information to the students, researcher and clinicians